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KMID : 0613820180280111332
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Journal of Life Science
2018 Volume.28 No. 11 p.1332 ~ p.1338
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Anti-neuroinflammatory Effects of a Locusta migratoria Ethanol Extract in LPS-stimulated BV-2 Microglia
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Lee Hwa-Jeong
Seo Min-Chul
Lee Joon-Ha
Kim In-Woo
Kim Sun-Young
Hwang In-Yeong
Kim Mi-Ae
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Abstract
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Activated microglia, induced by various pathogens, protect neurons and maintain homeostasis of the central nervous system (CNS). However, severe activation causes neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease because of the secretion of various neurotoxic molecules, such as nitric oxide (NO), prostaglandin (PG), and pro-inflammatory cytokines. Because chronic microglial activation endangers neuronal survival, negative regulators of microglial activation have been identified as potential therapeutic candidates for treatment of many neurological diseases. One potential source of these regulators is Locusta migratoria, a grasshopper of the Acrididae, usually 4-6 cm in size, belonging to the family of large insects in Acrididae. This grasshopper is an edible insect resource that can be consumed by humans as protein source or used for animal feed. The aim of the present study was to examine the inhibitory effects of a L. migratoria ethanol extract (LME) on the production of inflammatory mediators in LPS-stimulated BV-2 microglia cells. The extract significantly inhibited the NO, iNOS, COX-2, and pro-inflammatory cytokine (TNF-α, IL-6 and IL-1β) levels in BV-2 microglia cell. Because the inhibition of microglial activation may be an effective solution for treating brain disorders like Alzheimer’s and Parkinson’s diseases, these results suggest that LME may be a potential therapeutic agent for the treatment of brain disorders induced by neuroinflammation.
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KEYWORD
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BV-2 microglia, Locusta migratoria, neuroinflammation, nitric oxide, proinflammatory cytokine
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